Arab Americans are defined as people living in the United States with ancestry from at least one of the 22 states of the Arab League (Member states of the Arab League). There are currently an estimated 3.7 million Arab Americans … Read more

Pancreatic ductal adenocarcinoma (PDAC) is the third deadliest cancer in the United States with a dismal 5-year survival rate of 10%. 97% of PDAC cases are driven by mutations in the KRAS oncogene, a GTPase that regulates a myriad of … Read more

Alzheimer’s disease (AD) is characterized by the accumulation of waste proteins, often referred to as tangles, which are considered the primary contributor to neuronal death. The main component of these tangles is tau protein which undergoes modifications that correlate with … Read more

ONC201 is an anti-cancer imipridone in clinical trials for multiple malignancies. Novel ONC201 analogues (the TR compounds) with greater potency were identified, although the anti-cancer mechanism of these drugs remained poorly understood. The Graves lab recently identified the mitochondrial caseinolytic … Read more

Schizophrenia is a severe mental disorder that affects ~1% of the population. It is typically diagnosed during adolescence or early adulthood, and characterized by the presence of hallucinations, delusions, and grossly disorganized behavior. Antipsychotics are the primary treatment of these … Read more

Mu opioid receptors (μ receptors) play a critical role in the effects of opioids, including analgesia, opioid-induced hyperalgesia (OIH), tolerance, withdrawal, and locomotor-related behaviors, but which populations of receptors are the primary mediators of these processes is yet to be … Read more

Osteoporosis affects approximately 200 million people worldwide. One in three women and one in five men over fifty years old will experience an osteoporotic fracture. These rates climb with age, and all rates of osteoporosis are expected to increase by … Read more

Due to the unfortunately ubiquitous and deadly nature of cardiovascular diseases by blood clots, especially strokes and myocardial infarctions, the matter of finding effective treatments is of high priority. Tissue plasminogen activator (tPA) is the only drug treatment that is … Read more

Individuals with autism often have increased head size, or macrocephaly. Previous studies have described periods of premature heightened brain development that are typically followed by stunts in development to be indicative of neuropsychiatric disorders. A novel and more accurate process … Read more

Much literature identifies breastfeeding as one of the primary interventions for reducing infant mortality and improving women’s health globally. However, despite the existence and overall success of national breastfeeding intervention programs in the U.S., African American women persistently have lower … Read more