Worker protection is important to keeping our economy and society running. We aim to study occupational and behavioral circumstances leading to COVID-19 exposures in North Carolina workplaces, as part of a pilot project by the National Institute of Occupational Safety … Read more

Pancreatic ductal adenocarcinoma (PDAC) is driven by oncogenic activation of KRAS in over 95% of patients. Recent evidence suggests that mutant KRAS activation rewires cancer cell metabolism, altering mitochondrial morphology and function. Specifically, activation of the downstream RAF-MEK-ERK effector signaling … Read more

Mutations in the human ZMYND11 gene have been postulated as the cause of neurodevelopmental disorders such as autosomal dominant intellectual disability 30, the 10p15.3 microdeletion syndrome, and autism spectrum disorders. ZMYND11 encodes a nuclear protein that specifically binds variant histone … Read more

Background: Superfund is a federally funded program implemented by the US Environmental Protection Agency (EPA) to clean up hazardous waste sites. The National Priorities List (NPL) consists of Superfund sites that pose significant threats to the environment and human health. … Read more

Inorganic arsenic (iAs) is a ubiquitous toxic metal in the environment known to be detrimental to human health. More than 100 million people, including those in the United States, are at risk of exposure that exceeds the World Health Organization’s … Read more

The Robust Placental Clock (RPC) is an epigenetic clock based on placental tissue DNA methylation found to be a highly accurate estimator of gestational age. Through its use of 558 individual CpG sites to enhance gestational age prediction, the Robust … Read more

Toxic metals belong to a major class of contaminants that are ubiquitously present in the environment, representing a threat to human health. Exposure to toxic metals during pregnancy has been linked to adverse outcomes at birth and later in life. … Read more