DNA mismatch repair is essential for maintenance of genome stability. Mismatch repair (MMR) corrects errors made during DNA replication, including mismatches and insertion-deletion loops. This process enhances DNA replication by about 100 to 1000-fold by improving the accuracy of the … Read more
Since December 2019, COVID-19 continues to be a global pandemic and challenge public health systems worldwide. To end the pandemic, populations must acquire herd immunity by natural infections and vaccination efforts. My presentation addresses the challenges and solutions of modelling … Read more
The Human Immunodeficiency Virus-1 (HIV) and the Acquired Immunodeficiency syndrome (AIDS) it causes remain incurable. Much has been done to reduce the effects and transmissibility of the disease, with antiretroviral therapy (ART) being a prime example. However, it is necessary … Read more
Antigen presentation machinery is often downregulated on malignant cells, limiting recognition and killing by CD8 T cells. However, tumor cells express tumor-specific surface molecules, such as B7-H3 or mesothelin, that can be detected by chimeric antigen receptors (CAR) engineered on … Read more
Salience detection facilitates scanning and learning from environments, enabling organisms to focus on relevant stimuli in their visual field for the purpose of survival. Although the brain circuits that underlie this process center around the amygdala, the psychological mechanisms that … Read more
Lack of commercial viability impedes the development of new antibiotics and the last new class of antibiotic was approved in 2003. Therefore, improving the efficacy of pre-existing antibiotics is a promising strategy to address the antimicrobial resistance crisis. Vancomycin is … Read more
To determine which genetic mutations, or variants, are most relevant to patient care in the use of precision medicine, evidence for variant pathogenicity evaluation must be analyzed from existing scientific literature in a process known as variant curation. Hypothes.is is … Read more
Post-translational histone modifications (e.g., acetylation) are important mechanisms that contribute to gene transcription and expression. Misregulation of gene expression can lead to cancer or be devastating to embryonic development. The SAGA complex (Spt-Ada-Gcn5-acetyltransferase) is a yeast transcriptional co-activator that regulates … Read more
Lipid droplets (LDs) are a vital metabolic center of cells. Among other functions, LDs are specialized in storing diverse classes of lipids. LDs serve three critical purposes: LDs are energy reservoirs, a source for building-blocks for the organelle membrane system … Read more
